| Abstract: | The syntheses and biological activities of 4 analogues of the thyrotropin-releasing hormone (TRH) are described. In these analogues the histidine residue has been replaced by L -lysine, L -α,γ-diaminobutyric acid, β-(3-pyrazolyl)-L -alanine, and L-arginine. All analogues exhibited the characteristic biological responses of TRH. For the β-(3-pyrazolyl)-L -alanine analogue as well as for TRH the bioassays suggest an induction of a strong and rapid resynthesis of thyrotropin (TSH) in higher (μg) concentrations. |
