Synthesis,characterization, and in vitro antimicrobial and antitumor activities of some tetraphenylstibonium(V) carboxylates

Several hitherto unreported pentacoordinated tetraphenylstibonium(V) carboxylates of general formula (C₆H₅)₄SbL, where L = o‐OHC₆H₅COO , (C₆H₅)₂C(OH)COO , 2‐(6‐OCH₃C₁₀H₆)CH(CH₃)COO , ArCH(OH)COO (Ar = C₆H₅, p‐CF₃C₆H₄, and p OCH₃C₆H₄), have been prepared and characterized by elemental analysis, solid state IR, ¹H NMR, and ¹³C NMR spectra, conductivity, and molecular weight measurements. Spectroscopic data together with solution phase studies conform to the requirement of triagonal‐bipyramidal configuration for these compounds. They were tested for in vitro antifungal (against Aspergillus flavus and Aspergillus niger) and antibacterial (against Staphylococcus aureus and Klebsiella pneumoniae) activities. The in vitro antitumor activity of all stibonium carboxylates was examined against MCF‐7 cell line. A few of them were found to exhibit moderate to significant biological activity. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:688–693, 2008; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20498