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Flow-injection fluorimetric analysis of sulfamethoxazole in pharmaceutical preparations and biological fluids |
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| Authors: | Erroz C L Viñas P Córdoba M H |
| Institution: | Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, E-30071 Murcia, Spain |
| Abstract: | A fluorimetric procedure for the determination of sulfamethoxazole using flow injection analysis is proposed. A two channel system is optimized for the fluorescent reaction with o-phthaldialdehyde and β-mercaptoethanol. The detection limit is 0.007 μg/ml. No fluorescence is generated by the metabolite N-acetylated sulfamethoxazole. The method is applied to the determination of sulfamethoxazole in pharmaceuticals, urine and bovine serum samples without matrix interference problems. |
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