Trityl isothiocyanate support for solid-phase synthesis

Trityl isothiocyanate resin 1], prepared from commercially available trityl chloride resin, is a useful precursor of the trityl thiosemicarbazide resin 2]. This resin can be employed in the solid-phase synthesis of a variety of supported isatin beta-thiosemicarbazones 4] and their Mannich derivatives 6]. A variety of thioureas 7] can be easily prepared by the reaction of 1] with amines. The supported thioureas are directly and efficiently converted to 2-aminothiazole-5-carboxylates 8] by reaction with methyl 2-chloroacetoacetate.