Synthesis of indoles via palladium-catalyzed C-H activation of N-aryl amides followed by coupling with alkynes |
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| Authors: | Feng ZhouXiuling Han Xiyan Lu |
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| Affiliation: | State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People’s Republic of China |
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| Abstract: | A convenient and efficient method for the construction of indole skeleton was developed via Pd-catalyzed C-H activation of N-aryl amides and subsequent coupling with alkynes. Both stoichiometric and catalytic versions have been successfully achieved. |
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| Keywords: | Palladium C-H activation Indole N-aryl amide Alkyne |
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