Nanoarchitectonics in combat against bacterial infection using molecular,interfacial, and material tools |
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| Institution: | 1. Research Center for Functional Materials, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, Ibaraki, Japan;2. Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8577, Ibaraki, Japan;3. International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, Japan;4. Department of Advanced Materials Science, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561, Japan;1. Hebei Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao 066004, PR China;2. State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, PR China;1. State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, PR China;2. Hebei Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao 066004, PR China;3. National Engineering Research Center for Equipment and Technology of Cold Strip Rolling, Yanshan University, Qinhuangdao 066004, PR China;1. Stephenson Institute for Renewable Energy and Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, United Kingdom;2. HH Wills Physics Laboratory, Bristol Centre for Functional Nanomaterials, University of Bristol, Tyndall Avenue, Bristol BS8 1TL, United Kingdom |
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| Abstract: | Nanoarchitectonics, as a post-nanotechnology concept, is the methodology for constructing functional materials from nano-units, which bridges the gap between nanotechnology and materials science. The research accomplishes advocating nanoarchitectonics has increased dramatically as overviewed in the initial part of this review. Then, as socially impactful subjects, we exemplify nanoarchitectonics research for bacterial infections according to classifications featured with molecular tools, interfaces, and hierarchically structured materials. In particular, this review article discusses namely three kinds of antibacterial strategies: (i) new antimicrobial agents and therapeutic modalities based on nanoarchitectonics present high bactericidal efficacy against methicillin-resistant Staphylococcus aureus; (ii) antimicrobial nanoarchitectonics structures are integrated into the surface of medical devices to detach or kill approaching bacteria; (iii) the nanoarchitectonics hydrogels act as antimicrobial reservoirs to produce sustained-release antimicrobial agents for long-lasting bacterial killing. |
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| Keywords: | Antimicrobial agent Bacterial infection Hierarchically structured material Hydrogel Interface Molecular tool Nanoarchitectonics Surface Sustained release Therapeutic modality |
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