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Engineering antimicrobial surfaces by harnessing polymeric nanoassemblies
Institution:1. Department of Chemistry, University of Basel, Mattenstrasse 24a, 4058 Basel, Switzerland;2. NCCR-MSE, NCCR-Molecular Systems Engineering, BPR 1095, Mattenstrasse 24a, CH-4058 Basel, Switzerland;3. SNI, Swiss Nanoscience Institute, University of Basel, Klingelbergstrasse 82, CH-4056 Basel, Switzerland
Abstract:The increasing number of multidrug-resistant bacteria is a growing threat to global public health. Contaminated surfaces pose a major problem in the spreading of these superbugs and are a source of bacterial infections that are difficult to treat. Surfaces that repel bacteria or impede biofilms where bacteria are inaccessible to conventional drugs are in great demand for medical and technological applications. Immense multi-disciplinary efforts are being made to develop biocompatible, long-lasting, scalable, and cost-effective antimicrobial surfaces. Here, we highlight emerging strategies that involve harnessing natural and synthetic polymeric nanoassemblies that are antimicrobial either by themselves or through association with antimicrobial compounds to engineer antimicrobial surfaces. Our aim is to move underexplored nanoassemblies into the limelight. Based on their chemical versatility, structural tenability, and orthogonal activity of associated molecules and structures, the nanoassemblies discussed overcome cytotoxicity, non-biodegradability, and short-term antibacterial activity to offer novel surfaces with improved antibacterial and antibiofilm prospects.
Keywords:Antimicrobial surfaces  Polymer nanoassemblies  Surface immobilization
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