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Expression of Hepatoma-derived growth factor family members in the adult central nervous system
Authors:Heba M El-Tahir   Frank Dietz   Ralf Dringen   Kerstin Schwabe   Karen Strenge   S?rge Kelm   Mekky M Abouzied   Volkmar Gieselmann  Sebastian Franken
Affiliation:(1) Institut f?r Physiologische Chemie, Rheinische Friedrich-Wilhelms Universit?t, Nussallee 11, 53115 Bonn, Germany;(2) Centre for Biomolecular Interactions Bremen, Universit?t Bremen, 28359 Leobener Stra?e, Bremen, Germany;(3) Institut f?rHirnforschung, Universit?t Bremen, 28334 Leobener Stra?e, Bremen, Germany
Abstract:

Background  

Hepatoma-derived growth factor (HDGF) belongs to a polypeptide family containing five additional members called HDGF related proteins 1–4 (HRP-1 to -4) and Lens epithelial derived growth factor. Whereas some family members such as HDGF and HRP-2 are expressed in a wide range of tissues, the expression of others is very restricted. HRP-1 and -4 are only expressed in testis, HRP-3 only in the nervous system. Here we investigated the expression of HDGF, HRP-2 and HRP-3 in the central nervous system of adult mice on the cellular level by immunohistochemistry. In addition we performed Western blot analysis of various brain regions as well as neuronal and glial cell cultures.
Keywords:
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