Expression of Hepatoma-derived growth factor family members in the adult central nervous system |
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| Authors: | Heba M El-Tahir Frank Dietz Ralf Dringen Kerstin Schwabe Karen Strenge S?rge Kelm Mekky M Abouzied Volkmar Gieselmann and Sebastian Franken |
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| Institution: | (1) Institut f?r Physiologische Chemie, Rheinische Friedrich-Wilhelms Universit?t, Nussallee 11, 53115 Bonn, Germany;(2) Centre for Biomolecular Interactions Bremen, Universit?t Bremen, 28359 Leobener Stra?e, Bremen, Germany;(3) Institut f?rHirnforschung, Universit?t Bremen, 28334 Leobener Stra?e, Bremen, Germany |
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| Abstract: | Background Hepatoma-derived growth factor (HDGF) belongs to a polypeptide family containing five additional members called HDGF related
proteins 1–4 (HRP-1 to -4) and Lens epithelial derived growth factor. Whereas some family members such as HDGF and HRP-2 are
expressed in a wide range of tissues, the expression of others is very restricted. HRP-1 and -4 are only expressed in testis,
HRP-3 only in the nervous system. Here we investigated the expression of HDGF, HRP-2 and HRP-3 in the central nervous system
of adult mice on the cellular level by immunohistochemistry. In addition we performed Western blot analysis of various brain
regions as well as neuronal and glial cell cultures. |
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