Identification, cloning and characterization of a novel 47 kDa murine PKA C subunit homologous to human and bovine Cβ2 |
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| Authors: | Ane Funderud Heidi H Henanger Tilahun T Hafte Paul S Amieux Sigurd Ørstavik Bjørn S Skålhegg |
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| Affiliation: | (1) Department of Biology, California Institute of Technology Pasadena, Pasadena, CA 91125, USA;(2) Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815-6789, USA;(3) Department of Biology, Stanford University, Palo Alto, CA 94305, USA |
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| Abstract: | Background SCF ubiquitin ligases target numerous proteins for ubiquitin dependent proteolysis, including p27 and cyclin E. SCF and other cullin-RING ligases (CRLs) are regulated by the ubiquitin-like protein Nedd8 that covalently modifies the cullin subunit. The removal of Nedd8 is catalyzed by the Jab1/MPN domain metalloenzyme (JAMM) motif within the Csn5 subunit of the Cop9 Signalosome. |
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