Construction of Polyheterocyclic Compounds by Lewis Acid Mediated Intramolecular [3+2] Cycloaddition Reaction |
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| Authors: | Pooja Dahiya Anoop Yadav Rajnish Budhwan Prof. Dr. Rama Krishna Peddinti |
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| Affiliation: | Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667 Uttarakhand, India |
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| Abstract: | An efficient domino approach has been developed for the synthesis of polyheterocyclic derivatives constituting pyrrole moiety. Lewis acid catalyzed reaction of 2-substituted-2-hydroxy-indane-1,3-diones and 1,4-benzoxazinone derivatives resulted in the formation of polyheterocyclic compounds under metal-free and mild conditions in good to excellent yield. The reaction is highly regioselective for C−C and C−N bond construction proceeded via intramolecular [3+2] cycloaddition reaction. The protocol is highly efficient, obviates column chromatography and the products are obtained by simple filtration followed by washing with solvent. |
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| Keywords: | domino reactions cycloadditions heterocyclic compounds pyrrole-fused scaffolds synthetic methods |
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