Asymmetric Reductive Amination in Organocatalysis and Biocatalysis |
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Authors: | Tingting Li Qian Zhou Fanjing Meng Wenhui Cui Qian Li Jiang Zhu Yang Cao |
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Institution: | 1. Jiangsu Key Laboratory of Marine Pharmaceutical, Compound Screening, Jiangsu Ocean University, Lianyungang, Jiangsu, 222005 P. R. China;2. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, 430071 P. R. China |
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Abstract: | This review summarizes the recent progress of organocatalytic and biocatalytic asymmetric reductive amination (ARA), a challenging but important topic for drug discovery and the pharmaceutical industry. At present, ARA can be divided into three categories: metal catalysis, organic catalysis, and biocatalysis. In the past decade, transition metal-catalysed ARA has been well established. Organocatalytic ARA has emerged as a powerful alternative to metal-catalysed ARA, the hydrogen sources used in organocatalytic ARA are usually Hantzsch esters, benzothiazolines, boranes, and hydrosilanes, which require Lewis base or phosphoric acid catalysts to activate them to give secondary chiral amines. It is worth mentioning that biocatalytic ARA has made remarkable progress in the last decade, amino acid dehydrogenases, amine dehydrogenases, opine dehydrogenases and imine reductases have been successfully used in ARA. |
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Keywords: | asymmetric reductive amination biocatalysis chiral amines metal-free organocatalysis |
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