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Potassium Persulfate-Glucose Mediated Synthesis of (3)-S-Arylthioindoles from Indole and Thiophenols in Water |
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| Authors: | Nitin Kumar Dr Rapelly Venkatesh Prof Sundaram Singh Prof Jeyakumar Kandasamy |
| Institution: | 1. Department of Chemistry, Indian Institute of Technology (BHU), 221005 Varanasi, Uttar Pradesh, India
These authors contributed equally to this work.;2. Department of Chemistry, Pondicherry University, 605014 Pondicherry, India These authors contributed equally to this work.;3. Department of Chemistry, Indian Institute of Technology (BHU), 221005 Varanasi, Uttar Pradesh, India |
| Abstract: | An efficient and eco-friendly method has been developed for the preparation of functionalized 3-(S)-arylthioindoles in good to excellent yields from indoles and aryl thiols in water. The coupling reaction was prompted by K2S2O8 in the presence of glucose at room temperature. Broad substrate scope, functional group tolerance, room temperature reactions and metal-free conditions are the salient features of the developed methodology. |
| Keywords: | S-arylthioindole indole potassium persulfate thiophenol water |