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PPh3-Mediated Nucleophilic Sulfonation of Sulfonyl Chlorides with Arynes: Access to Manifold Aryl Sulfones |
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| Authors: | Hui-Qi Yue Qi-Wei Li Da-Wei Shi Rui-Jia Yang Dr Liang-Liang Han Dr Bin Yang |
| Institution: | 1. College of Chemistry and Chemical Engineering, Yantai University, Yantai, 264005 P. R. China
These authors contributed equally to this work.;2. College of Chemistry and Chemical Engineering, Yantai University, Yantai, 264005 P. R. China |
| Abstract: | Sulfonyl chlorides are a class of cheap and readily available basic chemicals, which have routinely served as electrophilic reagents in their chemical transformations. Herein, we disclose a novel PPh3-mediated nucleophilic sulfonation method of sulfonyl chlorides with arynes. Different from the classical P(III)-mediated reductive deoxygenation reaction of sulfonyl chlorides, the valence state of the sulfur atom has not been changed. This protocol exhibits broad functional group tolerance and provides a direct approach to a variety of aryl and alkyl sulfones. |
| Keywords: | arynes sulfonation sulfones sulfonyl chlorides triphenylphosphine |