Front Cover: Deoxygenative Intramolecular Minisci-Type Reaction to Access Fused Heterocyclic Scaffolds (Eur. J. Org. Chem. 7/2023) |
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Authors: | Francisco José Aguilar Troyano Khadijah Anwar Prof Dr Fabian Mohr Dr Guillaume Robert Dr Adrián Gómez-Suárez |
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Institution: | 1. Organic Chemistry, Bergische Universität Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany;2. Inorganic Chemistry, Bergische Universität Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany;3. Université Côte d'azur, INSERM, C3M Nice, France |
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Abstract: | Herein, we present a straightforward strategy for the synthesis of fused heterocycles through a deoxygenative, intramolecular Minisci-type reaction. This approach grants access to complex polycyclic scaffolds in three steps from readily available starting materials, such as chlorinated heteroarenes and 1,3-diols. The use of saccharide derivatives as the starting 1,3-diol motif allows for the synthesis of novel heterocyclic scaffolds with excellent diastereoselectivity and formal retention of configuration at the newly formed C−C bond. |
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Keywords: | Deoxygenation Heterocycles Minisci-type reaction Radical reactions |
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