Nickel-Catalyzed Electrochemical Synthesis of (Hetero)Aryl Trifluoromethyl Selenides |
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Authors: | Dr. Serhii Krykun Dr. Muriel Durandetti |
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Affiliation: | Laboratoire COBRA (UMR 6014 & FR 3038), Normandie Univ., UNIROUEN, INSA Rouen, CNRS, 76000 Rouen, France |
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Abstract: | A convenient and efficient approach for the construction of aryl trifluoromethyl selenoethers from aryl iodides under mild conditions is reported. Electrochemical activation of stable and inexpensive NiBr2bipy (bipy – bipyridine) complex instead of labile Ni(COD)2 (COD – cyclooctadiene) catalyst. [NMe4][SeCF3] is employed as shelf-stable source of SeCF3 fragment. The reaction tolerates a wide range of substrates, including modification of drug-like molecules. Cyclic voltammetry studies allow insight into the reaction mechanism. |
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Keywords: | C-Se bond formation electrosynthesis nickel catalysis selenium trifluoromethylselenolation |
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