Modular Synthesis of Phosphite and Phosphoramidite Ligands for Rh-Catalyzed Hydroformylation |
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| Authors: | Changjiang Li Zhaozhou Li Kunpeng Tan Prof?Dr Guodu Liu |
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| Institution: | Inner Mongolia Key Laboratory of Fine Organic Synthesis, College of Chemistry and Chemical Engineering, Inner Mongolia University (South Campus), 24 Zhaojun Rd., Hohhot, 010030 P. R. China |
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| Abstract: | Rhodium-catalyzed hydroformylation of olefins is an important method for synthesizing aldehydes, and it is worth noting that regioselectivity and enantioselectivity of the product controlled by ligand are the most commonly used strategies. The modular synthesis of phosphite and phosphoramidite ligands have significant advantages of simple synthesis and high catalytic activity, which was why these ligands have been widely used in hydroformylation reactions. Herein, we focus on the synthesis methods and design ideas of such ligands, as well as their application effects in hydroformylation reactions. This review aims to provide a reference for the design and synthesis of ligands in hydroformylation subsequently. |
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| Keywords: | hydroformylation modular synthesis phosphine ligands phosphite ligands phosphoramidite ligands |
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