A reexamination of Biginelli-like multicomponent condensation reaction: One-pot regioselective synthesis of spiro heterobicyclic rings |
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| Authors: | Ahmad Shaabani Ayoob Bazgir Hamid Reza Bijanzadeh |
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| Affiliation: | Department of Chemistry, Shahid Beheshti University, Zip Code 1983963113, Tehran, Iran. a-shaabani@cc.sbu.ac.ir |
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| Abstract: | A pseudo four-component reaction is described, leading to the efficient regioselective synthesis of sigma symmetric spiro heterobicyclic rings using aldehydes and urea in the presence of cyclic beta-diester or beta-diamides such as Meldrum's acid or barbituric acid derivatives. The reaction needs no added catalyst and proceeds solvent-free conditions at 80 degrees C. |
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| Keywords: | barbituric acid Biginelli reaction Meldrum's acid multicomponent solvent-free spiro heterobicyclic rings |
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