3,5-Nonadiyne isolated from the rhizome of Cachrys ferulacea inhibits endogenous nitric oxide release by rat peritoneal macrophages |
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| Authors: | Doković Dejan D Bulatović Vanja M Bozić Biljana D Kataranovski Milena V Zrakić Tomislav M Kovacević Nada N |
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| Affiliation: | Faculty of Chemistry, University of Belgrade, Serbia and Montenegro. dejandj@chem.bg.ac.yu |
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| Abstract: | 3,5-Nonadiyne, in vitro, selectively inhibits endogenous nitric oxide release (IC(50)=6.7+/-0.8 microM) by rat peritoneal macrophages at doses that do not inhibit T cell proliferation. 3,5-Nonadiyne was isolated from root essential oil of Cachrys ferulacea (L.) CALESTANI, synonym Prangos ferulacea (L.) LINDLEY, obtained by hydrodistillation and spectrometricaly identified unambiguously. |
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