Cyclization reactions of 4-(3′-butenyl)azetidin-2-one a route to the carbopenam ring system |
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Authors: | Tetsuo Aida Richard Legault Denise Dugat Tony Durst |
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Institution: | Department of Chemistry, University of Ottawa Ottawa, Canada, K1N 9B4 |
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Abstract: | Cyclization of 4-(3′-butenyl)azetidin-2-one, initiated by electrophilic reagents such as I2, Hg(OAc)2 results in the formation of bicyclic β-lactams having the carbopenam ring skeleton. Reaction of with Br2 results in simple addition of Br2 to the double bond, while PhSBr gives a mixture of cyclization and addition products. |
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