| 水溶性镧系位移试剂对羟基脯氨酸的手性识别 |
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| 引用本文： | 刘洋来,许美凤,颜贤忠. 水溶性镧系位移试剂对羟基脯氨酸的手性识别[J]. 波谱学杂志, 2012, 29(4): 521-529 |
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| 作者姓名： | 刘洋来 许美凤 颜贤忠 |
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| 作者单位： | 国家生物医学分析中心，北京 100850 |
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| 基金项目： | 国家科技重大专项"重大新药创制"资助项目 |
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| 摘 要： | 用1H NMR和13 C NMR研究了水溶性镧系位移试剂Sm-pdta对反式-4-羟基脯氨酸的手性识别. 反式-4-羟基脯氨酸与Sm-pdta形成络合物后，其1H NMR和13C NMR图谱的化学位移有所变化，手性碳附近的某些原子所对应的吸收峰裂分为2组信号，分别对应反式-4-羟基脯氨酸的两种对映异构体. 结果显示，对于反式-4-羟基脯胺酸, Sm-pdta是一个既方便又有效的手性位移试剂.
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| 关 键 词： | 核磁共振(NMR) 反式-4-羟基脯胺酸 Sm-pdta 手性位移试剂 手性识别 |
| 收稿时间： | 2012-02-03 |
Chiral Recognition of Hydroxyproline by Water-Soluble Chiral Lanthanide Shift Reagent |
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| LIU Yang-lai , XU Mei-feng , YAN Xian-zhong. Chiral Recognition of Hydroxyproline by Water-Soluble Chiral Lanthanide Shift Reagent[J]. Chinese Journal of Magnetic Resonance, 2012, 29(4): 521-529 |
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| Authors: | LIU Yang-lai XU Mei-feng YAN Xian-zhong |
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| Affiliation: | National Center of Biomedical Analysis, Beijing 100850, China |
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| Abstract: | 1H and 13C NMR spectroscopy was carried out to investigate the chiral recognition of trans-4-hydroxyproline using water-soluble chiral lanthanide shift reagent Sm-pdta. When complexed with Sm pdta, most signals in the 1H and 13C NMR spectra of trans-4-hydroxy-L- proline and trans-4-hydroxy-D-proline were shifted, leading to separation of the signals from the two enantiomers. The results showed that Sm-pdta is an effective reagent for chiral recognition of trans-4-hydroxyproline. |
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| Keywords: | NMR trans-4-hydroxyproline Sm-pdta chiral shift reagent chiral recognition |
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