Acerolide, a new cytotoxic cembranolide from the soft coral Pseudopterogorgia acerosa |
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| Authors: | Montalvo David Amade Philippe Funel-Le Bon Corinne Fernández Rogelio Reyes Fernando |
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| Institution: | Medicinal Chemistry Department, PharmaMar S.A., Pol. Ind. La Mina Norte. Avda. de los Reyes 1, 28770 (Colmenar Viejo) Madrid, Spain. |
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| Abstract: | A new cembranolide, acerolide (1) together with the known compound pseudopterolide (2) were isolated from the 2-propanol extract of the soft coral Pseudopterogorgia acerosa. The structure of 1 was determined on the basis of detailed spectroscopic analysis. Compound 1 showed moderate in vitro cytotoxicity against a panel of 14 tumor cell lines. |
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