Asymmetric hydroamination/cyclization catalyzed by group 4 metal complexes with chiral biaryl-based ligands |
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| Authors: | Guofu Zi |
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| Institution: | Department of Chemistry, Beijing Normal University, Beijing 100875, China |
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| Abstract: | Group 4 metal complexes based on chiral biaryl ligands are readily prepared by a convenient amine elimination procedure, and they are efficient catalysts for the asymmetric hydroamination/cyclization of aminoalkenes. The biaryl-based ligands are highly modular enabling facile tuning of the catalyst reactivity and selectivity. The corresponding heterocyclic products have been obtained in excellent enantiomeric excesses (up to 93%) using sterically hindered C2-symmetric titanium and zirconium mesitoylamidate complexes such as 1,1′-(C10H10)2-2,2′-{NCO(2,4,6-Me3C6H2)}2]M(NMe2)2 (M = Ti, Zr). These results are presented in this short review. |
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| Keywords: | Group 4 metals Chiral catalysts Asymmetric catalysis Hydroamination/cyclization |
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