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Synthesis and anticancer properties of gold(I) and silver(I) N-heterocyclic carbene complexes |
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| Authors: | Tammy J Siciliano Michael C Deblock Semih Durmus Claire A Tessier |
| Institution: | a Department of Chemistry, The Ohio State University at Mansfield, 1760 University Drive, Mansfield, OH 44906, USA b Integrated Bioscience Program, The University of Akron, Akron, OH 44325-3908, USA c Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA |
| Abstract: | Bis(1,3-dimethylimidazol-2-ylidene)silver(I) nitrate and bis(4,5-dichloro-1,3-dimethylimidazol-2-ylidene)silver(I) nitrate were prepared by reacting the corresponding imidazolium nitrate salts with silver oxide. Bis(1,3-dimethylimidazol-2-ylidene)gold(I) nitrate and bis(4,5-dichloro-1,3-dimethylimidazol-2-ylidene)gold(I) nitrate salts were prepared via transmetallation of their silver precursors with chloro dimethylsulfide gold. The anticancer properties were determined using NCI-H460 lung cancer cells. Efficacy was established by comparison of the gold and silver compounds with cisplatin. |
| Keywords: | Gold Silver N-Heterocyclic carbene Transmetallation Anticancer agent |
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