Ruthenium-catalyzed coupling reaction of 2,3,5-trisubstituted furans with aryl halides through C-H bond cleavages |
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| Authors: | Hua Cao Haiying Zhan Hong Zhao |
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| Institution: | a School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou 510006, PR China
b Lab Center of Zhongshan Campus, Guandong Pharmaceutical University, Zhongshan 528458, PR China |
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| Abstract: | A variety of functionalized furans were synthesized by way of a ruthenium-catalyzed coupling reaction of 2,3,5-trisubstituted furans with aryl halides through C-H bond cleavages. The feature of the reaction was facilitative preparation of furan derivatives good functional group tolerance. All reactions gave the desired products in moderate to good yields (56-89%) in the presences of RuCl2(p-cymene)] and K2CO3 in NMP at 120 °C. |
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| Keywords: | Ruthenium-catalyzed Coupling reaction Furans Aryl halides |
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