CuI-catalyzed tandem carbomagnesiation/carbonyl addition of Grignard reagents with acetylenic ketones: Convenient access to tetrasubstituted allylic alcohols |
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| Authors: | Meihua Xie Chengyou Feng Jitan Zhang Changqing Liu Kuang Fang Guanying Shu Wansheng Zuo |
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| Institution: | Key Laboratory of Functional Molecular Solids (Ministry of Education), Anhui Key Laboratory of Molecular Based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, China |
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| Abstract: | Highly functionalized tetrasubstituted allylic alcohols were prepared conveniently by CuI-catalyzed tandem carbomagnesiation/carbonyl addition of Grignard reagents with acetylenic ketones. The obtained allylic alcohols can be further transformed to polysubstituted indenes by intramolecular cyclization. |
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| Keywords: | Allylic alcohol Acetylenic ketone Grignard reagent CuI Indene |
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