An efficient and selective synthesis of 2,5-substituted pyrroles by gold-catalysed ring expansion of alkynyl aziridines |
| |
Authors: | Paul W. Davies Nicolas Martin |
| |
Affiliation: | School of Chemistry, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK |
| |
Abstract: | A range of substituted alkynyl aziridines undergo a ring expansion to afford 2,5-substituted pyrroles under gold catalysis. While effective conditions can be generated from other gold sources, a combination of Ph3PAuCl and AgOTs generate a catalyst system that provides extremely clean cycloisomerisation reactions requiring minimal work-up and purification. |
| |
Keywords: | Gold catalysis Pyrrole Cycloisomerisation Counterion |
本文献已被 ScienceDirect 等数据库收录! |