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Synthesis and in vitro antimalarial and antitubercular activity of gold(III) complexes containing thiosemicarbazone ligands |
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| Authors: | Setshaba D Khanye Scott G Franzblau Philip J Rosenthal Kelly Chibale |
| Institution: | a Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa b Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612-723, USA c Department of Medicine, San Francisco General Hospital, University of California at San Francisco, CA 94143, USA d Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa |
| Abstract: | Gold(III) thiosemicarbazone complexes derived from Au(damp-C1,N)Cl2] (2), where damp = dimeth-ylaminoethylphenyl, have been synthesized. The compounds were characterised using various spectroscopic and analytical techniques, including NMR spectroscopy, mass spectrometry, infrared spectroscopy and elemental analysis. The gold complexes were screened for in vitro antimalarial and antitubercular activity. Although incorporation of the gold(III) centre into thiosemicarbazone scaffolds enhanced their efficacy against the malaria parasite Plasmodium falciparum, this trend was not observed for the antitubercular activity of selected thiosemicarbazones against the Mycobacterium tuberculosis virulent strain H37Rv. |
| Keywords: | Gold Thiosemicarbazones Mycobacterium tuberculosis Plasmodium falciparum Antimalarial activity Antitubercular activity |
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