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Ferrocenylthiosemicarbazones conjugated to a poly(propyleneimine) dendrimer scaffold: Synthesis and in vitro antimalarial activity |
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| Authors: | Setshaba D Khanye Philip J Rosenthal Gregory S Smith |
| Institution: | a Department of Chemistry, University of Cape Town, Private Bag, Rondebosch 7701, South Africa b Department of Medicine, San Francisco General Hospital, University of California at San Francisco, CA 94143, USA c Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa |
| Abstract: | First-generation ferrocenylthiosemicarbazone metallodendrimers based on a poly(propyleneimine) dendrimer scaffold were synthesised with ferrocenylthiosemicarbazone moieties conjugated to the periphery of the branched polyamine scaffolds. The compounds were characterised by NMR and IR spectroscopy, elemental analysis and ESI-mass spectrometry. These new complexes were evaluated as bioorganometallic antimalarial agents against the Plasmodium falciparum chloroquine-resistant W2 strain. In vitro antiplasmodial assays of the dendritic ferrocenylthiosemicarbazones against the malaria parasite P. falciparum show increased efficacy compared to the precursor non-conjugated thioesters. |
| Keywords: | Bioorganometallic chemistry Poly(propyleneimine) Dendrimers Ferrocenylthiosemicarbazones Antimalarial activity |
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