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Effective synthesis of Tc tricarbonyl complexes by microwave heating
Authors:Naoya Harada  Masahiro Ono  Yoshiro Ohmomo  Hidekazu Kawashima
Institution:a Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan
b Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan
c Kyoto University Hospital, 54 Shogoin Kawahara-cho, Kyoto 606-8507, Japan
Abstract:Technetium-99m (99mTc) is one of the most frequently used nuclides for single-photon emission computed tomography (SPECT) imaging because of its radiochemical characteristics, such as gamma emission of suitable energy (141 keV) and adequate half-life (6.01 h). Although triaquatricarbonyl 99mTc cation (99mTc(CO)3(H2O)3]+) has several advantages as a 99mTc-labeling agent, e.g., compact chelate size, chelate stability, and simplicity of preparation, its synthetic protocols should be improved. Because microwave heating is a convenient method for synthetic reactions, we studied the effect of microwave irradiation on the synthesis of 99mTc tricarbonyl complexes. We found several factors beneficial for the preparation of nuclear medicines. In particular, microwave heating promoted one-pot syntheses of 99mTc tricarbonyl chelates in a short time. In addition, the 99mTc tricarbonyl complex could be obtained using low concentrations of ligands.
Keywords:99mTc tricarbonyl complex  Microwave heating  SPECT  Radiopharmaceutical
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