Synthesis and characterization of glycoconjugate tin(IV) complexes: In vitro DNA binding studies, cytotoxicity, and cell death |
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| Authors: | Sartaj Tabassum Rais Ahmad Khan Subrata Sen Aarti S. Juvekar |
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| Affiliation: | a Department of Chemistry, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh, India
b Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai 410210, Mumbai, India |
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| Abstract: | New glycosyl derived ligand and its complexes, with SnCl4·5H2O (1) and (CH3)2SnCl2(2) were synthesized and characterized by spectroscopic (IR, 1H, 13C, and 119Sn NMR, UV-vis, ESI-MS) and analytical methods. Interaction studies of 1 and 2 with CT DNA were studied by using various biophysical techniques, which showed high binding affinity of 2 with CT DNA. In vitro cytotoxicity of complexes 1 and 2 were evaluated against different human cancer cell lines of different histological origins by employing SRB Assay. The organotin(IV) complex 2 exhibited remarkable activity against DWD (oral cancer) cell lines with GI50 values <10 μg/ml. Complex 2 induced apoptosis of DWD cell line at a very low concentration of 1-4 μg/mL. |
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| Keywords: | Glycoconjugate-Sn(IV) complexes In vitro DNA binding studies Cytotoxicity Nuclear morphology |
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