First prebiotic generation of a ribonucleotide from adenine, D-ribose and trimetaphosphate |
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Authors: | Baccolini Graziano Boga Carla Micheletti Gabriele |
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Institution: | Department of Organic Chemistry A. Mangini ALMA MATER STUDIORUM-Università di Bologna Viale del Risorgimento, 4, Italy. baccolin@ms.fci.unibo.it |
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Abstract: | Adenosine monophosphate isomers are obtained by self-assembling of adenine, D-ribose and trimetaphosphate in aqueous solution in good yields. This generation of a ribonucleotide from its three molecular components occurs in a one-pot reaction at room temperature for about 30-40 days and with high chemio-, regio-, and stereo-selectivity. Similar results are obtained with guanine. A mechanism is also proposed. |
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