Ultrasensitive fluorescence polarization DNA detection by target assisted exonuclease III-catalyzed signal amplification |
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Authors: | Zhang Min Guan Yi-Meng Ye Bang-Ce |
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Affiliation: | Lab of Biosystems and Microanalysis, East China University of Science & Technology, Meilong RD 130, Shanghai, 200237, China. |
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Abstract: | Single stranded DNA sequences can be detected by target assisted exonuclease III-catalyzed signal amplification fluorescence polarization (TAECA-FP). The method offers an impressive detection limit of 83 aM within one hour for DNA detection and exhibits high discrimination ability even against a single base mismatch. |
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