Anionic inverse electron-demand 1,3-dipolar cycloaddition of nitrones with ynolates. Facile stereoselective synthesis of 5-isoxazolidinones leading to beta-amino acids |
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| Authors: | Shindo Mitsuru Itoh Kotaro Tsuchiya Chinatsu Shishido Kozo |
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| Affiliation: | Institute for Medicinal Resources, University of Tokushima, Sho-machi 1, Japan. shindo@ph2.tokushima-u.ac.jp |
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| Abstract: | [reaction: see text] The inverse electron-demand 1,3-dipolar cycloaddition of nitrones with ynolates, followed by quenching with t-BuOH, produced substituted 5-isoxazolidinones with good trans-selectivity. These products were easily converted into beta-amino acids. |
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