Highly enantioselective reformatsky reaction of ketones: chelation-assisted enantioface discrimination |
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| Authors: | Ojida Akio Yamano Toru Taya Naohiro Tasaka Akihiro |
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| Institution: | Medicinal Chemistry Research Laboratories, Takeda Chemical Industries, Ltd., Osaka 532-8686, Japan. |
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| Abstract: | reaction: see text] Highly enantioselective Reformatsky reaction of ketones was accomplished using cinchona alkaloids as chiral ligands. Chelation with the sp(2)-nitrogen adjacent to the reactive carbonyl center contributed the enantioface discrimination for the high enantioselectivities. |
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