Quinine and chloroquine differentially perturb heme monomer-dimer equilibrium |
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| Authors: | Casabianca Leah B An David Natarajan Jayakumar K Alumasa John N Roepe Paul D Wolf Christian de Dios Angel C |
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| Institution: | Department of Chemistry, Georgetown University, 37th and O Streets, NW, Washington, DC 20057, USA. |
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| Abstract: | Nuclear magnetic resonance (NMR) measurements of magnetic susceptibility have been utilized to study the equilibrium between two forms (high-spin monomer vs the antiferromagnetically coupled mu-oxo dimer) of ferriprotoporphyrin(IX) as a function of pH. The pH dependence of this equilibrium is significantly altered by the addition of either chloroquine or quinine. Chloroquine promotes the mu-oxo dimer whereas quinine promotes the monomer. |
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