Microwave-assisted synthesis,characterization and biological activity of novel pyrazole derivatives |
| |
| Affiliation: | 1. Department of Pharmaceutical Chemistry, PES’s Rajaram and Tarabai Bandekar College of Pharmacy, Faramagudi, Ponda 403 401, Goa, India;2. School of Pharmacy, UCSI (University College Sadaya International) University, Jalan Menara Gading, 56000 Cheras, Kuala Lumpur, Malaysia;3. Medicinal Chemistry Research Laboratory, Bapatla College of Pharmacy, Bapatla 522 101, Andhra Pradesh, India;4. Department of Medicinal Chemistry, DCRM Pharmacy College, Inkollu 523 167, Andhra Pradesh, India |
| |
| Abstract: | A series of 1-(4-substitutedphenyl)-3-phenyl-1H-pyrazole-4-carbaldehydes 4a–l have been synthesized and tested for their biological activities. Formation of the pyrazole derivatives was achieved by treating with Vilsmeier-Haack reagent. The newly synthesized compounds were evaluated for their anti-inflammatory and analgesic activities compared to Diclofenac sodium as standard drug. Compounds 4g, 4i and 4k exhibited the maximum anti-inflammatory and analgesic activities. The detailed synthesis, spectroscopic and toxicity data are reported. |
| |
| Keywords: | Pyrazole Anti-inflammatory activity Analgesic activity |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
