Tandem cyclopropane ring-opening/Conia-ene reactions of 2-alkynyl indoles: a [3 + 3] annulative route to tetrahydrocarbazoles |
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| Authors: | Grover Huck K Lebold Terry P Kerr Michael A |
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| Affiliation: | Department of Chemistry, The University of Western Ontario, London, Ontario, Canada N6A 5B7. |
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| Abstract: | A Zn(NTf(2))(2) catalyzed tandem reaction consisting of a nucelophilic ring opening of 1,1-cyclopropanediesters by 2-alkynyl indoles followed by a Conia-ene ring closure results in the efficient one-step synthesis of tetrahydrocarbazoles. The adducts may be further elaborated to carbazoles. |
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