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Sensitive method for the routine determination tricyclic antidepressants in plasma using a specific nitrogen detector. |
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| Authors: | L A Gifford P Turner C M Pare |
| Abstract: | The sensitivity of the alkali flame ionization detector to the tricyclic antidepressant drugs has been studied and limits of detection measured. A backflush system has been used to enable measurement in plasma extracts. A general method for the estimation of tricyclic plasma levels has been developed and exemplified by the measurement of imipramine at therapeutic levels. |
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