Halichonadins K and L, new dimeric sesquiterpenoids from a sponge Halichondria sp |
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Authors: | Tanaka Naonobu Suto Shohei Ishiyama Haruaki Kubota Takaaki Yamano Akihito Shiro Motoo Fromont Jane Kobayashi Jun'ichi |
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Institution: | Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. |
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Abstract: | Two new structurally unique dimeric sesquiterpenoids, halichonadins K (1) and L (2), were isolated from an Okinawan marine sponge Halichondria sp. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis including a single crystal X-ray diffraction analysis and chemical conversion. Halichonadins K (1) and L (2) are homodimers of the eudesmane sesquiterpene linked with a piperidine ring through amide bonds. Halichonadin K (1) showed moderate cytotoxicity against KB cells. |
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