Nanoindentation of gold nanoparticles functionalized with proteins |
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| Authors: | Heeyeon P Wampler Albena Ivanisevic |
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| Institution: | 1. UNC/NCSU Joint Department of Biomedical Engineering, North Carolina State University, Raleigh, NC, United States;2. Department of Materials Science and Engineering, North Carolina State University, Raleigh, NC, United States;3. Department of Molecular Biomedical Sciences, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States |
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| Abstract: | The hardness and Young's modulus of 10 and 20 nm gold nanoparticles (Au NPs) modified with bovine serum albumin and streptavidin were measured using a nanoindenter. The Au NPs were immobilized on a semiconductor surface through organic self-assembled monolayers. Changes in mechanical properties occurred when the Au NPs were immobilized on the surface. The hardness and Young's modulus were dependent on the size of the NPs, and the proteins on the particles showed highly plastic and elastic behavior compared to flat surfaces modified with self-assembled monolayers. |
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