Controlled Release of an Antihypertensive Drug through Interpenetrating Polymer Network Hydrogel Tablets of Tamarind Seed Polysaccharide and Sodium Alginate |
| |
| Authors: | Raghavendra V Kulkarni Vaibhav V Baraskar Vijaykumar V Alange Akram A Naikawadi Biswanath Sa |
| |
| Institution: | 1. Department of Pharmaceutical Technology , Bijapur Liberal District Education Association's College of Pharmacy , Bijapur , Karnataka , India;2. Department of Pharmacology, Shri. B.M. Patil Medical College , Bijapur Liberal District Education University , Bijapur , Karnataka , India;3. Division of Pharmaceutics, Department of Pharmaceutical Technology , Jadavpur University , Kolkata , India |
| |
| Abstract: | The application of interpenetrating polymer network (IPN) hydrogel tablets of tamarind seed polysaccharide and sodium alginate for controlled release of a water-soluble antihypertensive drug, propranolol HCl (PPL), was investigated. The IPN tablets loaded with PPL or PPL–resin complex (resinate) were prepared by a wet granulation/covalent cross-linking method. Fourier Transform Infrared Spectroscopic confirmed the cross-linking reaction and IPN formation, while X-ray Diffraction and Scanning Electron Microscopy studies confirmed the amorphous dispersion of the drug within the IPN tablets. The plain drug PPL showed complete release within 1 h, while drug release from the resinate was prolonged for 2.5 h and the IPN matrices showed drug release up to 24 h. The drug release rate from the IPN matrices was affected by polymer concentration and cross-linking time; the higher the cross-linking time, the slower was the drug release. The drug release mechanism was found to be of a non-Fickian type. |
| |
| Keywords: | drug release interpenetrating polymer network ion exchange resins sodium alginate tamarind seed polysaccharide |
|
|
