Biocatalytic Approach for the Total Synthesis of (–)‐Malyngolide and Its C(5)‐Epimer |
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| Authors: | Nikhil Srivastava Basi V Subba Reddy |
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| Institution: | 1. Natural Product Chemistry, CSIR‐Indian Institute of Chemical Technology, Hyderabad, India;2. +91‐40‐27193535+91‐40‐27160512 |
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| Abstract: | An enzymatic approach has been successfully utilized in the total synthesis of (–)‐malyngolide and its C(5)‐epimer. The required configuration was established by an enzymatic kinetic resolution and Sharpless asymmetric dihydroxylation. |
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| Keywords: | Malyngolide Antibiotic activity Enzymatic resolution Asymmetric dihydroxylation δ ‐Lactone |
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