Pseudonocardides A – G,New γ‐Butyrolactones from Marine‐derived Pseudonocardia sp. YIM M13669 |
| |
| Authors: | Xiao‐Mei Zhang Dao‐Feng Zhang Wen‐Jun Li Chun‐Hua Lu |
| |
| Institution: | 1. Yunnan Institute of Microbiology, Yunnan University, Kunming, P. R. China;2. Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, P. R. China;3. +86‐871‐65033335;4. State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat‐Sen University, Guangzhou, P. R. China;5. +86‐531‐88382108 |
| |
| Abstract: | Seven new γ‐butyrolactones, named pseudonocardides A – G ( 1 – 7 ), were isolated from the marine‐derived actinomycete strain Pseudonocardia sp. YIM M13669. Their structures were elucidated on the basis of spectroscopic data including 1D‐ and 2D‐NMR, and HR‐ESI‐MS. The absolute configuration of 1 was determined by X‐ray crystallographic analysis of 1a (4‐bromobenzoate derivative of 1 ). The antibacterial activity against Mycobacterium smegmatis MC2155 and cytotoxicities of compounds 1 – 7 were evaluated in this study. |
| |
| Keywords: | γ ‐Butyrolactones Pseudonocardides A – G
Pseudonocardia
X‐Ray crystallography Antibacterial activity |
|
|
