New ent‐Pimarane Diterpenes from the Roots of Aralia dumetorum |
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| Authors: | Chun‐Tao Yang Shu‐Qun Hou Kai Tian Qiu‐Fen Hu Xiang‐Zhong Huang Zhi‐Yong Jiang |
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| Institution: | 1. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Chenggong New District, Kunming, Yunnan, P. R. China;2. +86 871 65952171+86 871 65910017;3. Key Laboratory of Comprehensive Utilization of Mineral Resources in Ethnic Regions, Yunnan Minzu University, Kunming, P. R. China;4. Key Laboratory of Yi Medicine Resources & Pharmacodynamics Research, Yunnan Minzu University, Chenggong New District, Kunming, Yunnan, P. R. China;5. +86 871 65926040 |
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| Abstract: | Four new ent‐pimarane diterpenes were isolated from the EtOH extract of Aralia dumetorum, together with three known compounds involving ent‐pimar‐8(14),15‐dien‐19‐oic acid ( 5 ), ent‐pimar‐8(14),15‐dien‐19‐ol ( 6 ), and ent‐kaur‐16‐en‐19‐oic acid ( 7 ). By detailed analyses of the MS, IR, and NMR data, the structures of four new diterpenes were characterized as (5β,9β,10α,13α)‐pimara‐6,8(14),15‐trien‐18‐oic acid ( 1 ), (5β,7β,9β,10α,13α)‐7‐methoxypimara‐8(14),15‐dien‐18‐oic acid ( 2 ), (5β,9β,10α,13α,14β)‐14‐methoxypimara‐7,15‐dien‐18‐oic acid ( 3 ), and (5β,10α,13α,14α)‐14‐hydroxypimara‐7,9(11),15‐trien‐18‐oic acid ( 4 ). The cytotoxic activities of compounds 1 – 7 were assayed in vitro through MTT method. |
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| Keywords: |
Aralia dumetorum
ent‐Pimarane diterpenes Cytotoxic activity |
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