Identification of Two New Phosphorylated Polyketides from a Brazilian Streptomyces sp. Through the Use of LC–SPE/NMR |
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| Authors: | Sérgio Scherrer Thomasi Cecília Ladeira Douglas Ferreira Ricardo da Fontoura Sprenger Alberto Colli Badino Antonio Gilberto Ferreira Tiago Venâncio |
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| Affiliation: | 1. ?55‐35‐38291075;2. Departamento de Química, Universidade Federal de Lavras, Lavras, MG, Brazil;3. Departamento de Engenharia Química, Universidade Federal de S?o Carlos, S?o Carlos, SP, Brazil;4. Departamento de Química, Universidade Federal de S?o Carlos, S?o Carlos, SP, Brazil |
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| Abstract: | Two new polyketide phosphate monoesters, phosdiecin A ( 1 ) and phosdiecin B ( 2 ), were isolated from a culture of the marine Streptomyces sp. SS99BA‐2 using the hyphenated technology LC–SPE/NMR. The compounds showed to be new representatives of an important class of antitumor antibiotic metabolites known as fostriecins. Their structures, including relative configuration attribution, were fully elucidated through extensive analyses of NMR and MALDI‐TOF/TOF HR‐MS data. Herein, the application of this system to isolate and identify the new compounds is described. |
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| Keywords: |
Streptomyces
Polyketides Phosdiecin A and B |
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