Total synthesis of 3,5-O-dicaffeoylquinic acid and its derivatives |
| |
| Authors: | K Saki Raheem Nigel P Botting Gary WilliamsonDenis Barron |
| |
| Institution: | a School of Chemistry, University of St. Andrews, KY16 9ST Scotland, UK
b Nestle Research Center, PO Box 44, CH-1000, Lausanne 26, Switzerland |
| |
| Abstract: | We report the first total synthesis of 3,5-O-dicaffeoylquinic acid and its derivatives, 3,5-O-diferuloylquinic acid and 3,5-(3,4-dimethoxycinnamyl)quinic acid, in a nine-step sequence. The key step involves Knoevenagel condensations between vanillin, 3,4-dimethoxybenzaldehyde or 4-hydroxy-3-methoxybenzaldehyde and the dimalonate ester of quinic acid. |
| |
| Keywords: | Dicaffeoylquinic acids Natural product synthesis Knoevenagel condensation Metabolism references Plant natural products |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
