Improved Hiyama cross-coupling reactions using HOMSi® reagents: a novel application of a palladacycle |
| |
| Authors: | Sebastian M Marcuccio Ruwan EpaMaisa Moslmani Andrew B Hughes |
| |
| Institution: | a Department of Chemistry, La Trobe University, Melbourne, Victoria 3086, Australia
b Advanced Molecular Technologies Pty Ltd, Unit 1/7-11 Rocco Drive, Scoresby, Victoria 3179, Australia |
| |
| Abstract: | Various parameters in the Hiyama cross-coupling reaction of HOMSi® reagents with ethyl bromobenzoate were studied. These included solvent, ligand, palladium source, and added water. DMF and THF were found to be excellent solvents. Palladium chloride was found to be the best palladium source and no added water was required. The use of tri-o-tolylphosphine as the ligand proved to be particularly effective. |
| |
| Keywords: | HOMSi® Hiyama reaction Palladacycle Tri-o-tolylphosphine Cross-coupling |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
