Activity of the acyl-CoA synthetase ACSL6 isoforms: role of the fatty acid Gate-domains |
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Authors: | Eric Soupene Nghi Phuong Dinh Melvin Siliakus Frans A Kuypers |
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Institution: | (1) Children's Hospital Oakland Research Institute, Oakland, California 94609, USA |
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Abstract: | Background Activation of fatty acids by acyl-CoA synthetase enzymes is required for de novo lipid synthesis, fatty acid catabolism, and remodeling of biological membranes. Human long-chain acyl-CoA synthetase member
6, ASCL6, is a form present in the plasma membrane of cells. Splicing events affecting the amino-terminus and alternative
motifs near the ATP-binding site generate different isoforms of ACSL6. |
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