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BRCA1 involved in regulation of Bcl-2 expression and apoptosis susceptibility to ionizing radiation |
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| Authors: | WANG YanLing WANG Bing ZHANG Hong LI Ning TANAKA Kaoru ZHOU Xin CHEN RuPing & ZHANG Xin |
| Institution: | WANG YanLing1,2,3,WANG Bing5,ZHANG Hong1,3*,LI Ning1,4,TANAKA Kaoru5,ZHOU Xin1,CHEN RuPing6 & ZHANG Xin1,4 1 Institute of Modern Physics,Chinese Academy of Sciences,Lanzhou 730000,China,2 Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences,3 Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province,4 Graduate University of Chinese Academy of Sciences,Beijing 100049,5 Radiation Haza... |
| Abstract: | BRCA1 has been proposed to be tightly linked to the resistance of tumor cells to ionizing radiation. The pathway leading to this phenomenon is not yet clear. In this work, we investigated the role of BRCA1 in the apoptosis regulation in response to carbon ion irradiation. We utilized three different cancer cell lines with various states for BRCA1 and p53 to identify the relationship between endogenous BRCA1 and the apoptosis-related genes, and determine whether p53 function would affect the role of BRCA1 in... |
| Keywords: | BRCA1 p53 Bax Bcl-2 apoptosis ionizing radiation |
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